Multiple sclerosis or encephalomyelitis disseminata is a condition that affects the spinal cord and brain. The component that is affected is mainly the protective cover or myelin sheath. One the sheath has been damaged, the function of the nervous system is compromised and this results in a number of signs and symptoms that may manifest both psychologically and physically. In a number of patients, these signs and symptoms resolve completely while in others it may result in serious complications. MS prevention aims at avoiding both the symptoms and complications in susceptible individuals.
The aetiological factors of this condition are a combination of both genetic and environmental factors. Certain genetic variations have been shown to increase the risk of MS. The risk is higher in relatives of the affected individual with probability increasing among those very closely related. Identical twins have the highest chance of being victims, followed by fraternal twins, siblings and step siblings in that order. Predisposition is ten times higher when both parents are victims.
The role for microbes is backed by two theories namely the hygiene theory and the prevalent theory. In the hygiene theory, a microbe will only result into MS on a second exposure. The first exposure causes an immunological reaction that is protective. In the prevalent theory, it is said that certain microorganisms are associated with geographical areas known to have a high prevalence of the condition and thus are thought to play a role.
Several risk factors are thought to greatly contribute to worsening of MS. These factors include occupational exposure to toxins, smoking, hormonal treatments, stress, diet and vaccination among others. Avoiding these factors and behaviors is said to lower the risk of the condition significantly.
Pathologically, there are three main features of MS including formation of lesions, inflammation and damage to myelin sheaths. Interaction of these characteristics results in breakdown of nervous tissue and hence physical manifestation of signs and symptoms. Damage is also believed to be caused by an autoimmune reaction in the body.
Four main clinical courses exist. These are the progressive relapsing, the relapsing remitting, and the primary and secondary progressive. All have varying features and varying degrees of severity. The secondary progressive is the commonest and affects about 65% of individuals with the disease. The relapsing remitting is characterized by recurrence after treatment.
Whenever an attack occurs, the initial priority should be to restore the CNS function and to prevent subsequent attacks. Efforts to avoid permanent disability should also be made. A number of pharmacological agents have been found to be helpful in delaying the progression of disease. The leading agents are beta interferon and glatiramer. Prompt treatment of flu particularly in the months following delivery in women.
High levels of temperature have been established to be a factor that worsens the signs and symptoms. They lead to the deterioration of the nerves that have already been affected and for this reason they should be avoided at all costs. If air conditioners are available, they should always be put in sue. Hot swimming pools and tubs are to be avoided. MS prevention, as seen here, involves the removal of any exacerbating factors.
The aetiological factors of this condition are a combination of both genetic and environmental factors. Certain genetic variations have been shown to increase the risk of MS. The risk is higher in relatives of the affected individual with probability increasing among those very closely related. Identical twins have the highest chance of being victims, followed by fraternal twins, siblings and step siblings in that order. Predisposition is ten times higher when both parents are victims.
The role for microbes is backed by two theories namely the hygiene theory and the prevalent theory. In the hygiene theory, a microbe will only result into MS on a second exposure. The first exposure causes an immunological reaction that is protective. In the prevalent theory, it is said that certain microorganisms are associated with geographical areas known to have a high prevalence of the condition and thus are thought to play a role.
Several risk factors are thought to greatly contribute to worsening of MS. These factors include occupational exposure to toxins, smoking, hormonal treatments, stress, diet and vaccination among others. Avoiding these factors and behaviors is said to lower the risk of the condition significantly.
Pathologically, there are three main features of MS including formation of lesions, inflammation and damage to myelin sheaths. Interaction of these characteristics results in breakdown of nervous tissue and hence physical manifestation of signs and symptoms. Damage is also believed to be caused by an autoimmune reaction in the body.
Four main clinical courses exist. These are the progressive relapsing, the relapsing remitting, and the primary and secondary progressive. All have varying features and varying degrees of severity. The secondary progressive is the commonest and affects about 65% of individuals with the disease. The relapsing remitting is characterized by recurrence after treatment.
Whenever an attack occurs, the initial priority should be to restore the CNS function and to prevent subsequent attacks. Efforts to avoid permanent disability should also be made. A number of pharmacological agents have been found to be helpful in delaying the progression of disease. The leading agents are beta interferon and glatiramer. Prompt treatment of flu particularly in the months following delivery in women.
High levels of temperature have been established to be a factor that worsens the signs and symptoms. They lead to the deterioration of the nerves that have already been affected and for this reason they should be avoided at all costs. If air conditioners are available, they should always be put in sue. Hot swimming pools and tubs are to be avoided. MS prevention, as seen here, involves the removal of any exacerbating factors.
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